التفاصيل البيبلوغرافية
| العنوان: |
Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy. |
| المؤلفون: |
ESCAMILLA-TILCH, MONICA, TORRES-CARRILLO, NORA MAGDALENA, RAMOS PAYAN, ROSALIO, AGUILAR-MEDINA, MARIBEL, SALAZAR, MA ISABEL, FAFUTIS-MORRIS, MARY, ARENAS-GUZMAN, ROBERTO, ESTRADA-PARRA, SERGIO, ESTRADA-GARCIA, IRIS, GRANADOS, JULIO |
| المصدر: |
Biomedical Reports; 2013, Vol. 1 Issue 6, p945-949, 5p |
| مصطلحات موضوعية: |
HANSEN'S disease, DISEASE prevalence, DISEASE susceptibility, MYCOBACTERIUM leprae genetics, IMMUNE response, GENETICS |
| مستخلص: |
Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P<0.001, odds ratio (OR)=4.6, 95% confidence interval (95% CI): 1.8-11.4; and P=0.03, OR=6.2, 95% CI: 1.1-31.6, respectively] and the frequency of the HLA-DRB1*08 allele was found to be significantly lower among leprosy patients compared to controls (P=0.046, OR=2.4, 95% CI: 1-5.8). In conclusion, although the association of the HLA-DR locus with leprosy has been established in different populations and several studies have demonstrated significant differences in the DR alleles, this study demonstrated an association of the HLA-DRB1*01 allele with susceptibility to lepromatous and dimorphic leprosy, as well as an association of the HLA-DRB1*08 allele with protection against leprosy in a Mexican Mestizo population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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