التفاصيل البيبلوغرافية
| العنوان: |
P68 RNA helicase as a molecular target for cancer therapy. |
| المؤلفون: |
Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran, Chun-Meng Shi |
| المصدر: |
Journal of Experimental & Clinical Cancer Research (17569966); 2014, Vol. 33 Issue 1, p1-19, 19p |
| مصطلحات موضوعية: |
RNA helicase, CANCER treatment, ADENOSINE triphosphatase, TRANSCRIPTION factors, ACETYLATION, ESTROGEN receptors, RIBOSOMES |
| مستخلص: |
The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and RNA helicase ability, p68 can also function as a co-activator for transcription factors such as estrogen receptor alpha, tumor suppressor p53 and betacatenin. More than that, post-translational modification of p68 including phosphorylation, acetylation, sumoylation, and ubiquitylation can regulate the coactivation effect. Furthermore, aberrant expression of p68 in cancers highlights that p68 plays an important role for tumorgenesis and development. In this review, we briefly introduce the function and modulation of p68 in cancer cells, and put forward envisagement about future study about p68. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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