التفاصيل البيبلوغرافية
| العنوان: |
Association of MMP but not TIMP-1 gene polymorphisms with recurrent aphthous stomatitis. |
| المؤلفون: |
Karasneh, JA, Bani‐Hani, ME, Alkhateeb, AM, Hassan, AF, Thornhill, MH |
| المصدر: |
Oral Diseases; Oct2014, Vol. 20 Issue 7, p693-699, 7p, 5 Charts |
| مصطلحات موضوعية: |
DISEASE relapse, ACADEMIC medical centers, BLOOD testing, CHI-squared test, CONFIDENCE intervals, GENES, GENETIC polymorphisms, METALLOPROTEINS, MULTIVARIATE analysis, POLYMERASE chain reaction, REGRESSION analysis, RESEARCH funding, STATISTICS, T-test (Statistics), LOGISTIC regression analysis, DATA analysis, SEVERITY of illness index, CANKER sores, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, GENETICS |
| مصطلحات جغرافية: |
JORDAN |
| مستخلص: |
Objectives Recurrent aphthous stomatitis ( RAS) is a common oral inflammatory disease induced by genetic and environmental factors. Gelatinases ( MMP-2 and MMP-9) and their natural inhibitor TIMP-1 are active players in the inflammatory process. We aimed to determine whether inheritance of specific MMP-2, MMP-9, or TIMP-1 gene polymorphisms is associated with RAS susceptibility. Subjects and methods Ninety-six RAS patients and 153 healthy controls were studied. Five polymorphisms were genotyped: rs17576, rs3918242, and rs11697325 in MMP-9, MMP-2 rs2285053, and TIMP-1 rs6609533. Association was assessed by logistic regression analysis after adjustment for confounding factors. Linkage disequilibrium ( LD) was assessed using the Haploview program. Results MMP-9 rs11697325 was significantly associated with RAS, with an increase in the AA genotype in patients, determined using χ2 analysis ( OR = 2.3, P = 0.006) and adjusted regression analysis ( OR = 3.1, P = 0.009). MMP-9 rs11697325 and rs17576 showed strong LD ( D' = 0.95), with an increase in the AA haplotype ( P = 0.023) and a decrease in the GA haplotype ( P = 0.015) in patients. Conclusions This is the first study to investigate the association of MMPs or TIMP-1 with RAS. We found a significant association between MMP-9 rs11697325 polymorphisms and RAS. Confirmatory studies in other populations and functional investigations are needed to determine the role of these genes in RAS. [ABSTRACT FROM AUTHOR] |
|
Copyright of Oral Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder