Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A NovelPotent and Selective Inhibitor of Vps34 for the Treatment of SolidTumors.

التفاصيل البيبلوغرافية
العنوان:	Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A NovelPotent and Selective Inhibitor of Vps34 for the Treatment of SolidTumors.
المؤلفون:	Pasquier, Benoit, El-Ahmad, Youssef, Filoche-Rommé, Bruno, Dureuil, Christine, Fassy, Florence, Abecassis, Pierre-Yves, Mathieu, Magali, Bertrand, Thomas, Benard, Tsiala, Barrière, Cédric, El Batti, Samira, Letallec, Jean-Philippe, Sonnefraud, Véronique, Brollo, Maurice, Delbarre, Laurence, Loyau, Véronique, Pilorge, Fabienne, Bertin, Luc, Richepin, Patrick, Arigon, Jérôme
المصدر:	Journal of Medicinal Chemistry; Jan2015, Vol. 58 Issue 1, p376-400, 25p
قاعدة البيانات:	Supplemental Index

الوصف
تدمد:	00222623
DOI:	10.1021/jm5013352