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Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma.

التفاصيل البيبلوغرافية
العنوان: Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma.
المؤلفون: Souza Freitas V, de Andrade Santos PP, de Almeida Freitas R, Pereira Pinto L, de Souza LB
المصدر: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology; Sep2011, Vol. 112 Issue 3, p342-348, 7p
مستخلص: OBJECTIVES: The aim of this study was to evaluate mast cell (MC) density and migration and their association with matrix metalloproteinase (MMP) 9 expression in squamous cell carcinoma (SCC) and actinic cheilitis (AC). STUDY DESIGN: Tryptase, c-Kit, and MMP-9 expression was evaluated in 20 cases of SCC, 20 cases of AC, and 7 cases of normal lip (control samples) by immunohistochemistry techniques. RESULTS: Tryptase(+) and c-Kit(+) MC densities were significantly higher in SCCs than in ACs and control samples (P < .001). However, no significant difference was found when comparing tryptase(+) and c-Kit(+) MC densities between ACs and control samples (P values .185 and .516, respectively). MMP-9 was strongly expressed in SCCs and moderately expressed in ACs and control samples. A highly significant association was found between tryptase(+) MC density and the expression of MMP-9 (P < .001). CONCLUSIONS: The increase in MC density associated with the strong expression of MMP-9 may favor SCC progression. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات: Supplemental Index
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تدمد:10792104