Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.

التفاصيل البيبلوغرافية
العنوان:	Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
المؤلفون:	Graceffa, Russell F., Boezio, Alessandro A., Able, Jessica, Altmann, Steven, Berry, Loren M., Boezio, Christiane, Butler, John R., Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F., Dineen, Thomas A., Feric Bojic, Elma, Foti, Robert S., Fremeau, Robert T., Guzman-Perez, Angel, Hua Gao, Gunaydin, Hakan, Hongbing Huang, Liyue Huang, Ilch, Christopher
المصدر:	Journal of Medicinal Chemistry; 7/27/2017, Vol. 60 Issue 14, p5990-6017, 28p
قاعدة البيانات:	Supplemental Index

الوصف
تدمد:	00222623
DOI:	10.1021/acs.jmedchem.6b01850