التفاصيل البيبلوغرافية
| العنوان: |
Generation and characterization of induced pluripotent stem cell line (IGIBi001-A) from a sickle cell anemia patient with homozygous β-globin mutation. |
| المؤلفون: |
Bhargava, Nupur, Jaitly, Shashank, Goswami, Sangam Giri, Jain, Suman, Chakraborty, Debojyoti, Ramalingam, Sivaprakash |
| المصدر: |
Stem Cell Research; Aug2019, Vol. 39, pN.PAG-N.PAG, 1p |
| مستخلص: |
Sickle cell disease (SCD) is an autosomal recessive disorder caused by a mutation in β-globin (HBB) gene. We have generated an induced pluripotent stem cell (iPSC) line, IGIBi001-A from an Indian sickle cell patient with a homozygous HBB gene mutation using Sendai virus reprogramming system. Characterization of IGIBi001-A showed that these iPSCs are transgene-free and expressed pluripotent stem cell markers. They had a normal karyotype and were able to differentiate into all three germ layers. This new SCD-iPSC line will contribute to better understanding of the disease biology of sickle cell anemia and for screening of small molecule drugs. [ABSTRACT FROM AUTHOR] |
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