التفاصيل البيبلوغرافية
| العنوان: |
IMMUNOHISTOCHEMICAL EXPRESSION OF METALLOPROTEINASES AND TFN-Α BY MACROPHAGES AND LANGERHANS CELLS IN RADICULAR CYSTS. |
| المؤلفون: |
Farias, Danielle Machado, De França, Glória Maria, De Figueiredo Pires, Hévila, Oliveira, Marvin Felipe, De Andrade, Ana Luiza Dias Leite, De Andrade Santos, Pedro Paulo, Galvão, Hébel Cavalcanti |
| المصدر: |
Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Sep2022, Vol. 134 Issue 3, pe215-e216, 2p |
| مستخلص: |
This research aimed to evaluate the relationship between Langerhans cells, macrophages, matrix metalloproteinases (MMPs-9, -13), and tumor necrosis factor (TNF)-α in the lining epithelium of cystic lesions to elucidate the cyst expansion. A sectional and retrospective study was performed with 20 radicular cysts (RCs) and 20 residual radicular cysts (RRCs) by anti-CD68, anti-CD1a, anti-MMP-9, anti-MMP-13, and anti-TNF-α antibodies. The immunoexpression of MMP-13 and CD68 was significantly higher in RCs when compared to RRCs (P =.011 and P =.012, respectively). An intense inflammatory infiltrate was significantly correlated with CD68 immunoexpression in RCs (P =.025). Macrophages demonstrated a significant positive correlation with MMP-13 (P =.015). A moderate correlation was observed between MMP-9 and MMP-13 (P =.01). TNF-α expression was more common in RCs (P =.001). Langerhans cells were more frequently expressed in atrophic epithelium (P =.041) and significantly correlated with TNF-α (P =.014) in RCs. Macrophages induce a greater release of TNF-α. Higher immunoexpression of MMP-13 and MMP-9 is observed in the early stages of RCs compared to RRCs. The microorganisms are the main factors triggering a proinflammatory immune response and greater cystic expansion in the early stages of these cysts. [ABSTRACT FROM AUTHOR] |
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