التفاصيل البيبلوغرافية
| العنوان: |
Chapter Three - B cell responses to the gut microbiota. |
| المؤلفون: |
Ng, Kevin W., Hobbs, Alvaro, Wichmann, Christopher, Victora, Gabriel D., Donaldson, Gregory P. |
| المصدر: |
Advances in Immunology; 2022, Vol. 155, p95-131, 37p |
| مصطلحات موضوعية: |
B cells, GUT microbiome, GERMINAL centers |
| مستخلص: |
Most antibody produced by humans originates from mucosal B cell responses. The rules, mechanisms, and outcomes of this process are distinct from B cell responses to infection. Within the context of the intestine, we discuss the induction of follicular B cell responses by microbiota, the development and maintenance of mucosal antibody-secreting cells, and the unusual impacts of mucosal antibody on commensal bacteria. Much remains to be learned about the interplay between B cells and the microbiota, but past and present work hints at a complex, nuanced relationship that may be critical to the way the mammalian gut fosters a beneficial microbial ecosystem. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Supplemental Index |
