التفاصيل البيبلوغرافية
| العنوان: |
SARS-CoV-2 Infection after Effects: Multi-Organ Damage through Oxygen Radicals. |
| المؤلفون: |
Datta, Debatosh, Singh, Rajveer, Velayutham, Ravichandiran, Bhattacharya, Arka, Ray, Ujjwayini, Dasgupta, Sarbani, Dutta, Soma, Saha, Aditi, Roy, Debabrata, Ghosh, Srinika, Arumugam, Somasundaram, Datta, Pallab, Ganguly, N. K. |
| المصدر: |
Apollo Medicine; Oct-Dec2022, Vol. 19 Issue 4, p251-255, 5p |
| مصطلحات موضوعية: |
FLOW cytometry, ECHOCARDIOGRAPHY, COVID-19, POST-acute COVID-19 syndrome, MULTIPLE organ failure, SUPEROXIDE dismutase, APOPTOSIS, RISK assessment, REACTIVE oxygen species, DISEASE risk factors, DISEASE complications |
| مستخلص: |
Introduction: SARS-CoV-2 respiratory infection leads to two-layered pathology in time (a) immediate pathology and recovery or fatal ending and (b) long periods of remission followed by unexplained clinical expressions involving one or more systems with various clinical presentations, even leading to loss of lives. Among the common causative factors affecting nearly all organs and systems, oxygen radicals and oxygen-derived species (ROS) should rank conclusively on top. Objective: This clinical report, part of a community screening of unexplained clinical outcomes in post-COVID presentation, carries findings focusing on ROS production and possible ROS-induced damages. Materials and Methods: Flow cytometry was used to quantify the samples' total ROS, superoxide production, and apoptosis quantification. Results: Observations indicate unexplained nearly uniform enhanced ROS production in all these long COVID subjects, although clinical presentations varied from no complaints to the requirement of advanced interventions. Conclusion: Causative factors leading to raised oxygen-derived toxic intermediaries (ROS) in initiating these variable long COVID presentations are ill-understood yet possibly merit mass screenings and possible intense anti-oxidative therapy given that such antioxidant therapy through oral medications led to rapid lowering of ROS production and improvement of clinical presentations. [ABSTRACT FROM AUTHOR] |
|
Copyright of Apollo Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
Full Text Finder