التفاصيل البيبلوغرافية
| العنوان: |
Immigration and Cognitive Change after age 90: findings from the LifeAfter90 Study. |
| المؤلفون: |
Meunier, Claire C., Corrada, Maria M., Gilsanz, Paola, Kawas, Claudia H., Mungas, Dan M., DeCarli, Charles S., Meyer, Oanh L., Whitmer, Rachel A. |
| المصدر: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 7, Vol. 18 Issue 7, p1-2, 2p |
| مستخلص: |
Background: Prior studies have suggested immigration may be associated with different cognitive decline; however, this has not been explored in those aged 90+ years. This study examined the association between United States (US) born vs non‐US born and cognitive decline in a diverse cohort of oldest‐old. Method: We followed 641 participants of the LifeAfter90 study, an ongoing cohort study to evaluate aging and incident dementia in individuals aged 90+ recruited from Kaiser Permanente Northern California. Verbal episodic memory (VEM), semantic memory (SM), and executive function (EF) were measured using the Spanish and English Neuropsychological Assessment Scale every six months and domain‐specific scores were z‐scored to baseline. Self‐reported birthplace was collected at baseline or visit 2 (if previously not asked due to changes in the survey). Linear mixed models with random intercepts and slopes were adjusted for baseline age, gender, race/ethnicity, education, years since baseline, and practice effects. Result: The sample was comprised of 60% women, 30% White, 18% Latino, 22% African American, 22% Asian, and 8% multiracial individuals (Table 1). Nineteen percent (n = 123) of the participants was born outside of the US, of those, 74% identified as Asian or Latino. Average baseline age was 93 years without differences between US‐born and non‐US born participants. Participants were followed for up to 7 waves (3.5 years with a mean of 2 visits). At baseline, participants born outside of the US had lower EF z‐scores (β = ‐0.39; 95% CI:‐0.57,‐0.21) and lower SM z‐scores (β = ‐0.69; 95% CI:‐0.87,‐0.51) than US‐born counterparts after adjustments (Table 2, Model 3). Participants had similar rates of cognitive change in the EF and VEM domains over the 7 waves. Participants born outside the US had a faster rate of decline in SM (β = ‐0.14; 95% CI:‐0.26,‐0.03) after adjusting for covariates. Conclusion: In oldest‐old individuals, we found that those born outside of the US had lower baseline EF and SM; a faster rate of decline in SM and a similar, though not quite significant, effect on VEM decline. Further comprehensive data on immigration, such as age of immigration and educational opportunities, may help explain the relationship between cognitive function and immigration [ABSTRACT FROM AUTHOR] |
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