دورية أكاديمية

Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.
المؤلفون: Bodewes, F.T.H., van Asselt, A.A., Dorrius, M.D., Greuter, M.J.W., de Bock, G.H.
المصدر: Breast; Dec2022, Vol. 66, p62-68, 7p
مصطلحات موضوعية: BREAST cancer, DISEASE risk factors, DIGITAL mammography, DENSITY, ODDS ratio
مستخلص: Mammographic density is a well-defined risk factor for breast cancer and having extremely dense breast tissue is associated with a one-to six-fold increased risk of breast cancer. However, it is questioned whether this increased risk estimate is applicable to current breast density classification methods. Therefore, the aim of this study was to further investigate and clarify the association between mammographic density and breast cancer risk based on current literature. Medline, Embase and Web of Science were systematically searched for articles published since 2013, that used BI-RADS lexicon 5th edition and incorporated data on digital mammography. Crude and maximally confounder-adjusted data were pooled in odds ratios (ORs) using random-effects models. Heterogeneity regarding breast cancer risks were investigated using I2 statistic, stratified and sensitivity analyses. Nine observational studies were included. Having extremely dense breast tissue (BI-RADS density D) resulted in a 2.11-fold (95% CI 1.84–2.42) increased breast cancer risk compared to having scattered dense breast tissue (BI-RADS density B). Sensitivity analysis showed that when only using data that had adjusted for age and BMI, the breast cancer risk was 1.83-fold (95% CI 1.52–2.21) increased. Both results were statistically significant and homogenous. Mammographic breast density BI-RADS D is associated with an approximately two-fold increased risk of breast cancer compared to having BI-RADS density B in general population women. This is a novel and lower risk estimate compared to previously reported and might be explained due to the use of digital mammography and BI-RADS lexicon 5th edition. • So far, breast density was linked to a one-to sixfold increased breast cancer risk. • Prior risk estimates were based on old BI-RADS lexicon and screen-film mammography. • We included only studies using digital mammography and BI-RADS lexicon 5th edition. • Breast density D is associated with a two-fold increased risk of breast cancer. • This is a lower risk estimate compared to previously reported studies. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات: Supplemental Index
الوصف
تدمد:09609776
DOI:10.1016/j.breast.2022.09.007