التفاصيل البيبلوغرافية
| العنوان: |
Topical application of cream containing enriched-schizandrin from Schisandra chinensis fruit exert anti-photoaging efficacy in ultraviolet B-irradicated hairless mice. |
| المؤلفون: |
Mi-Young Yun, Nam-San Kim, Hwa-Jung Choi |
| المصدر: |
Pakistan Journal of Pharmaceutical Sciences; May2023, Vol. 36 Issue 3, p887-894, 8p |
| مستخلص: |
Excessive ultraviolet (UV) B irradiation induced skin photoaging. The aim of this study was to evaluate the anti-photoaging efficacy of enriched-schizandrin from Schisandra chinensis fruit in UVB-induced hairless mice. The cream containing enriched-schizandrin from S. chinensis fruit manufactured with another cosmetic ingredient. UVB-photoaged hairless mice topically applied with the cream once a day for 5 weeks. Application of the cream showed normal changes of body weight and food efficiency in the UVB-photoaged hairless mice. The cream application also was decreased interleukin (IL)-1β, matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expressions and then it inhibited MMP-2 protein expression in UVB-photoaged hairless mice. Furthermore, the cream application inhibited epidermal wrinkle formation and decreased wrinkle depth and it restored to wrinkle thickness and collagen degradation of skin in UVB-photoaged hairless mice. Therefore, the cream could recover photoaging generated by UVB irradiation via downregulation of IL-1β, MMP-2, MMP-9 mRNA expressions and suppression of expression of MMP-2 proteins. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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