التفاصيل البيبلوغرافية
العنوان: |
Can a low dosage of recombinant human bone morphogenetic protein-2 loaded on collagen sponge induce ectopic bone? |
المؤلفون: |
Alruwaili, Mohammed Katib, Tsutomu SUGAYA, Yasuhito MORIMOTO, Ko NAKANISHI, Tsukasa AKASAKA, Yasuhiro YOSHIDA |
المصدر: |
Dental Materials Journal; 2023, Vol. 42 Issue 3, p433-440, 8p |
مصطلحات موضوعية: |
BONE growth, COLLAGEN, BONE regeneration, X-ray computed microtomography, GROWTH factors, POLYMETHYLMETHACRYLATE, POLYCAPROLACTONE |
مستخلص: |
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is one of the growth factors that may induce the formation of new bone. The aim was to determine the efficacy of low doses of rhBMP-2 for bone regeneration using a collagen sponge as a carrier. Three doses of rhBMP-2 (1.167, 0.117, and 0.039 mg/mL) were combined with an absorbable collagen sponge (ACS) as a delivery vehicle. The rhBMP-2/ACS implants were placed in the subcutaneous tissues of rat backs. X-ray microcomputed tomography (micro-CT) and histological analysis were used to evaluate bone formation. The samples treated with 1.167 mg/mL of rhBMP-2 showed greater bone formation than the samples treated with 0.117 mg/mL of rhBMP-2 four weeks after surgery. However, there was no evidence of bone formation in the samples that were treated with 0.039 mg/mL of rhBMP-2. It was found that rhBMP-2 was osteogenic even at one-tenth of its manufacturer's recommended concentration (1.167 mg/mL), indicating its potential for clinical use at lower concentrations. [ABSTRACT FROM AUTHOR] |
|
Copyright of Dental Materials Journal is the property of Japanese Society for Dental Materials & Devices and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Supplemental Index |