التفاصيل البيبلوغرافية
| العنوان: |
Late positive potential component and cognitive functioning in occipital area of Mild Cognitive Impairment. |
| المؤلفون: |
Zhang, Zhenyu, Aleman, André, Opmeer, Esther, De Deyn, Peter Paul, Reesink, Fransje E, Spikman, Jacoba M, Herrmann, Christoph S, Wardana, Nido Dipo, Enriquez‐Geppert, Stefanie, Lejko, Nena, Ćurčić‐Blake, Branislava |
| المصدر: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 17, Vol. 19, p1-1, 1p |
| مستخلص: |
Background: Mild Cognitive Impairment (MCI) is a prodromal stage of Alzheimer's disease and other dementias (Langa & Levine, 2014). It has been suggested that a late event‐related potential (ERP) called the late positive potential (LPP) is related to cognitive functioning including sustained attention and reaction time in people with MCI (Waninger et al., 2018). The LPP in the occipital area was also suggested to be a biomarker of MCI (Liu et al., 2022). However, it remains unclear whether LPP in the occipital area is related to cognitive functioning. Method: We collected EEG of 50 people with MCI (mean age 72.44±7.96; education: 5.52±1.07) by using a 20‐channel EEG recording system while participants performed the simple vigilance task (SVT). Their reaction time (ms) was taken as a measure of sustained attention. Vienna Reaction Time Task (VRTT) (Schuhfried GmbH, Moedling, Austria) was used to measure processing speed and inhibition while separating motor action (measured as a motor time) and cognitive processing (measured as a reaction time). Mini‐Mental State Examination (MMSE) was used to measure the severity of cognitive impairment (mean score: 26.20±2.44). Correlation analysis was used to analyze the liner relationship between the average LPP amplitude in the occipital areas (Oz, O1, and O2; time window: 400 to 800 ms after stimulus presentation), reaction time on the three versions of the VRTT, and reaction time on the SVT. Result: We found significant correlations between reaction time on the SVT and motor time on VRTT (S1: p = 0.015; S2: p = 0.075; S3: p = 0.021;), but we found no significant correlations between reaction time on the SVT and VRTT (ps > 0.193), no significant correlations between LPP amplitude in the occipital areas and reaction time on any of the tasks (SVT: p > 0.056, VRTT: ps > 0.288) or between LPP amplitude and motor time on any version of the VRTT (ps > 0.500). Conclusion: Our preliminary results indicate that LPP amplitude measured over the occipital area was not significantly associated with sustained attention or inhibition. [ABSTRACT FROM AUTHOR] |
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