التفاصيل البيبلوغرافية
| العنوان: |
The diagnostic performance of plasma amyloid β, total tau and neurofilament light chain levels in mild cognitive impairment and Alzheimer's disease dementia: the Health & Aging Brain among Latino Elders study. |
| المؤلفون: |
Wang, Shanshan, Hall, James, Petersen, Melissa, O'Bryant, Sid E., Nandy, Rajesh |
| المصدر: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 15, Vol. 19, p1-4, 4p |
| مستخلص: |
Background: The current diagnostic criteria for Alzheimer's disease (AD) rely on neuroimaging and cerebrospinal fluid, which are expensive and invasive. Plasma‐based ATN biomarkers, including amyloid β40 (Aβ40), amyloid β42 (Aβ42), total tau, and neurofilament light chain (NfL), are more accessible and cost‐effective. However, the diagnostic performance of plasma‐based ATN biomarkers remains to be determined. This study aims to assess the diagnostic performances of plasma‐based ATN biomarkers for AD dementia and mild cognitive impairment (MCI), and assess whether the diagnostic performances are different between Mexican Americans and non‐Hispanic Whites. Method: We used data from the Health & Aging Brain among Latino Elders (HABLE) study. A total of 1616 participants (1260 cognitively normal, 247 MCI, and 109 AD dementia) were included in the analyses. Diagnoses of AD dementia and MCI were adjudicated by consensus review. Plasma was analyzed using the single molecule array (Simoa) assays. The overall diagnostic performances of plasma‐based ATN biomarkers were assessed by the area under the curve (AUC) analyses. The DeLong test was used to compare the AUCs. Result: Plasma NfL had better differentiation performances than plasma Aβ42/Aβ40 ratio, total tau and the combination of plasma ATN biomarkers. When age and sex were combined to the diagnostic model, the AUCs did not change significantly. The performances of plasma ATN biomarkers were not significantly different between Mexican Americans and non‐Hispanic Whites (P values>0.05). However, when age and sex were incorporated to the diagnostic model, the performances to distinguish AD dementia and MCI vs. CN, AD dementia vs. MCI, and MCI vs. CN were significantly different between Mexican Americans and non‐Hispanic Whites (P values<0.05). Conclusion: The current study provided more evidence on the potential capacity of plasma‐based ATN biomarkers for diagnosing AD among Mexican Americans and non‐Hispanic Whites. Overall, the diagnostic capacities of plasma ATN biomarkers were not ideal. More research is needed to explore the utilization of plasma ATN biomarkers. [ABSTRACT FROM AUTHOR] |
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