التفاصيل البيبلوغرافية
| العنوان: |
Effects of voluntary wheel running exercise on mice with polymyositis and the role of p62. |
| المؤلفون: |
Koichi Himori, Mami Yamada, Mitsuharu Okutsu |
| المصدر: |
Advances in Exercise & Sports Physiology; Mar2024, Vol. 29 Issue 4, p90-90, 1/2p |
| مستخلص: |
Purpose: In this study, we investigated the mechanism by which endurance exercise ameliorates the decline in endurance exercise capacity caused by polymyositis, focusing on p62, an autophagy substrate. Methods: In experiment 1, C57BL/6J mice were induced with experimental autoimmune myositis (EAM) and subjected to voluntary wheel running exercise for 4 weeks. In experiment 2, muscle-specific p62 knockout mice and wild-type mice were subjected to voluntary wheel running exercise after induction of EAM. Results: Endurance exercise ameliorated EAM-induced impairment of endurance exercise capacity and increased phosphorylation of p62. These exercise effects were accompanied by activation of mitochondrial biosynthesis and fast-to-slow fiber type transitions. Moreover, the endurance exercise capacity of p62 knockout EAM mice was improved by endurance exercise as in wild-type EAM mice, and the extent of this improvement did not differ by genotype. Discussion: The present results suggest that voluntary wheel running exercise improves endurance exercise capacity in EAM mice via increased mitochondrial mass and altered muscle fiber type, whereas p62 may not be involved in this improvement. [ABSTRACT FROM AUTHOR] |
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