التفاصيل البيبلوغرافية
| العنوان: |
Beneficial Effects of High-Intensity Interval Training and Dietary Changes Intervention on Hepatic Fat Accumulation in HFD-Induced Obese Rats. |
| المؤلفون: |
Xin-Meng YUAN, Meng-Qi XIANG, Ye PING, Pei-Wen ZHANG, Yu-Ting LIU, Xiao-Wei LIU, Juan WEI, Qiang TANG, Yuan ZHANG |
| المصدر: |
Physiological Research; Apr2024, Vol. 73 Issue 2, p273-284, 12p |
| مصطلحات موضوعية: |
HIGH-fat diet, HIGH-intensity interval training, PHYSICAL activity, DYSLIPIDEMIA, LIPID synthesis, OBESITY |
| مستخلص: |
Lifestyle intervention encompassing nutrition and physical activity are effective strategies to prevent progressive lipid deposition in the liver. This study aimed to explore the effect of dietary change, and/or high-intensity interval training (HIIT) on hepatic lipid accumulation in high fat diet (HFD)-induced obese rats. We divided lean rats into lean control (LC) or HIIT groups (LH), and obese rats into obese normal chow diet (ND) control (ONC) or HIIT groups (ONH) and obese HFD control (OHC) or HIIT groups (OHH). We found that dietary or HIIT intervention significantly decreased body weight and the risk of dyslipidemia, prevented hepatic lipid accumulation. HIIT significantly improved mitochondrial fatty acid oxidation through upregulating mitochondrial enzyme activities, mitochondrial function and AMPK/PPARα/CPT1α pathway, as well as inhibiting hepatic de novo lipogenesis in obese HFD rats. These findings indicate that dietary alone or HIIT intervention powerfully improve intrahepatic storage of fat in diet induced obese rats. [ABSTRACT FROM AUTHOR] |
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