التفاصيل البيبلوغرافية
| العنوان: |
A one-two punch strategy for diabetic wound management based on an antibiotic-hybrid biomineralized iron sulfide nanoparticle. |
| المؤلفون: |
Deng, Shuangpiao, Ou, Kaixin, Zhang, Chenyu, Yuan, Daojing, Cai, Xiaowen, Li, Fengtan, Wang, Xuetao, Yin, Jing, Xu, Chuanshan, Li, Yanli, Gong, Teng |
| المصدر: |
Acta Biomaterialia; Jun2024, Vol. 181, p333-346, 14p |
| مصطلحات موضوعية: |
WOUND healing, IRON sulfides, NANOPARTICLES, CHRONIC wounds & injuries, WOUNDS & injuries, TISSUE remodeling |
| مستخلص: |
Bacterial infection and immune imbalance are the primary culprits behind chronic wounds in individuals with diabetes, impeding the progression of damaged tissues towards normal healing. To achieve a harmonious balance between pro- and anti-inflammation within these infected areas, herein, we propose a one-two punch strategy for on-demand therapy of diabetes-infected wounds, utilizing an azithromycin (AZM)-hybrid nanocomposite termed GOx@Fe x S y /AZM. During the infective stage, the nanocomposite facilitates the production of ROS, coupled with the burst release of AZM and H 2 S gas, effectively dismantling biofilms and achieving rapid sterilization. Subsequently, the hyperinflammatory response induced by antibiosis is significantly mitigated through the synergistic action of tissue H 2 S and the prolonged half-life of AZM. These components inhibit the activity of pro-inflammatory transcription factors (AP-1 and NF-κB) within macrophages, thereby promoting the polarization of macrophages towards a reparative M2 phenotype and facilitating tissue remodeling. By catering to the diverse requirements of wound healing at different stages, this nanocomposite accelerates a sensible transition from inflammation to the reparative phase. In summary, this one-two punch strategy gives an instructive instance for procedural treatment of diabetes wound infection. The treatment of diabetic wound infection presents two major challenges: the diminished antibacterial efficacy arising from biofilm formation and bacterial resistance, as well as the inadequate transition of the wound microenvironment from pro-inflammatory to anti-inflammatory states after bacterial clearance. In this work, a biomineralized iron sulfide nanocomposite was prepared to mediate cascade catalytic (ROS storm) / antibiotic (AZM) / gas (H 2 S) triple-synergetic antibacterial therapy during the initial stage of bacterial infection, achieving the goal of rapid bactericidal effect; Subsequently, the residual H 2 S and long half-life AZM would inhibit the key pro-inflammatory transcription factors and promote the macrophages polarization to reparative M2, which effectively mediated tissue repair after hyperinflammatory reactions, leading to orderly treatment of hyperglycemic infected wounds. [Display omitted] [ABSTRACT FROM AUTHOR] |
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