التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of the effect of small single intravenous dose of amiodarone on the prevention of arrhythmias in patients who underwent coronary artery bypass graft surgery: A randomized controlled trial. |
| المؤلفون: |
Azemati, Simin, Dehghanpisheh, Laleh, Vatankhah, Pooya, Khademi, Saeed, Ghazinour, Mohammad, Eghdami, Sima |
| المصدر: |
Journal of Arrhythmia; Jun2024, Vol. 40 Issue 3, p529-535, 7p |
| مصطلحات موضوعية: |
ARRHYTHMIA prevention, ATRIAL fibrillation prevention, PHYSIOLOGIC salines, T-test (Statistics), STATISTICAL sampling, BLIND experiment, FISHER exact test, AMIODARONE, RANDOMIZED controlled trials, VENTRICULAR fibrillation, DESCRIPTIVE statistics, CHI-squared test, INTRAVENOUS therapy, CORONARY artery bypass, AORTA, DRUG efficacy, INTENSIVE care units, ADRENERGIC beta blockers, ATRIAL fibrillation, LENGTH of stay in hospitals, SURGICAL instruments, DATA analysis software, COMPARATIVE studies, DISEASE incidence |
| مصطلحات جغرافية: |
IRAN |
| مستخلص: |
Background: Atrial fibrillation (AF) is the most frequent arrhythmia after cardiac surgery causing a range of clinical symptoms and treatments that develop in around one-third of coronary artery bypass surgery patients. We aimed to evaluate the effect of Amiodarone in preventing arrhythmia in patients undergoing coronary artery bypass surgery. Method: In this double-blind randomized clinical trial, 60 patients candidate for coronary artery bypass surgery above the age of 18 were included and randomly divided into two groups of intervention, receiving an infusion of Amiodarone (3 mg/kg) 10 min (in 100 cc Normal saline) before declamping of the aorta, and a control group, receiving 100 cc of saline 10 min before declamping of the aorta. The patient's demographic, clinical features, and hospital and clinical course were recorded. Results: After undergoing operation, 22 (36.67%) of patients were developed arrhythmia. The Amiodarone group demonstrated significantly lower reperfusion ventricular fibrillation (RVF) rates (26.7% vs. 70%; p = .001) and AF occurrence (13.3% vs. 60%; p < .001) during the initial 24 h after surgery compared to the placebo group. There was no significant difference between the two groups regarding the need for D/C shock after removing the aortic clamp. (p = .117) Furthermore, the intensive care unit stay among the amiodaron group was significantly lower than the control group (2.43 vs. 3.07 days; p = .013). Conclusion: The predictive properties in the administration of single intravenous low-dose Amiodarone 10 min before the declamping of the aorta can significantly lower the rates of RVF and AF after coronary artery bypass grafting, while also decreasing hospitalization duration. [ABSTRACT FROM AUTHOR] |
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