التفاصيل البيبلوغرافية
| العنوان: |
Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease. |
| المؤلفون: |
Pott, Gregory B., Palmer, Brent E., Sullivan, Andrew K., Silviera, Lori, Maier, Lisa A., Newman, Lee S., Kotzin, Brian L., Fontenot, Andrew P. |
| المصدر: |
Journal of Allergy & Clinical Immunology; May2005, Vol. 115 Issue 5, p1036-1042, 7p |
| مصطلحات موضوعية: |
BERYLLIUM, CYTOKINES, T cells, BRONCHOALVEOLAR lavage |
| مستخلص: |
Background: Beryllium sensitization is caused by exposure to beryllium in the workplace. A subset of beryllium-sensitized (BeS) subjects progress to chronic beryllium disease (CBD), a disorder characterized by a CD4+ T-cell alveolitis and granulomatous inflammation. Whether biomarkers are present in blood that would allow separation of CBD from beryllium sensitization without invasive pulmonary procedures is unknown. Objective: The aim of this study was to determine whether the quantity of beryllium-specific T cells in blood of patients with CBD differs from that found in BeS subjects. Methods: Beryllium-induced T-cell proliferation and TH1-type cytokine secretion were determined in blood cells from 33 patients with CBD and 18 BeS subjects. Results: We demonstrate here that patients with CBD have a significantly elevated number of IFN-γ–producing and IL-2–producing beryllium-specific CD4+ T cells in blood compared with both BeS and normal control subjects. In contrast, no difference in beryllium-induced proliferation of blood T cells was seen between BeS patients and patients with CBD. Compared with the blood beryllium lymphocyte proliferation test, which detected beryllium-induced proliferation in 65% of BeS patients and patients with CBD, ELISPOT analysis detected IFN-γ secretion in 80% of these subjects. Higher numbers of beryllium-specific cells in blood were also associated with the extent of alveolar inflammation, as measured by both bronchoalveolar lavage white blood cell and lymphocyte counts. Conclusion: The frequency of beryllium-specific T cells in the blood of beryllium-exposed subjects may be a useful biomarker that helps discriminate between beryllium sensitization and progression to CBD. [Copyright &y& Elsevier] |
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