التفاصيل البيبلوغرافية
| العنوان: |
Estimating human age in forensic samples by analysis of telomere repeats. |
| المؤلفون: |
Karlsson, Andreas O., Svensson, Anna, Marklund, Annika, Holmlund, Gunilla |
| المصدر: |
Forensic Science International: Genetics Supplement Series; Aug2008, Vol. 1 Issue 1, p569-571, 3p |
| مصطلحات موضوعية: |
AGE determination of human beings, TELOMERES, IDENTIFICATION, CRIME scene searches, BLOODSTAINS, POLYMERASE chain reaction, FORENSIC sciences |
| مستخلص: |
Abstract: Within the area of forensics it would be of great help, both for identifications and in crime scene investigations, to be able to do an age estimate on humans simply on the basis of for instance bloodstains. Telomeres, that constitute the ends of human chromosomes, shorten with every cell division. Thus, telomere length might be used as an indicator of the biological and also of the chronological age of a human. A real-time PCR assay, to measure telomere repeats, was performed to evaluate the use of telomeres as an age estimating tool. In a test based on nearly 100 blood donors of different ages, the standard error of prediction of age estimates was approximately 22 years. This is too high to be of any use in forensic applications. A separate test showed that the telomeres were significantly shorter when analysing samples from the same individuals taken 20 years apart, but the variation among individuals was persistently large. Furthermore, a significant difference could be seen between the telomere lengths in blood and buccal swab samples; telomeres were significantly longer in the cells of the oral cavity. Common for all tests in this study was the relatively large variation between individuals of similar age. Biological factors such as disease and lifestyle most probably affect the actual telomere length, as well as inherited telomere length and telomerase activity. [Copyright &y& Elsevier] |
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