التفاصيل البيبلوغرافية
| العنوان: |
In-Depth Analysis of the Origins of HIV Type 1 Subtype C in South America. |
| المؤلفون: |
Leandro R. Jones, Darío A. Dilernia, Julieta M. Manrique, Franco Moretti, Horacio Salomón, Manuel Gomez-Carrillo |
| المصدر: |
AIDS Research & Human Retroviruses; Oct2009, Vol. 25 Issue 10, p951-959, 9p |
| مستخلص: |
AbstractThe South American HIV-1 epidemic is characterized by the cocirculation of subtype B and BF recombinant variants. Together with the B and BF genotypes, HIV-1 subtype C (HIV-1C), F1, and several other recombinants have been reported. The epidemiological significance and immune correlates of these “non-B-non-BF” strains circulating in South America are still uncertain and therefore are increasingly attracting the interest of the scientific community. In this study, the South American HIV-1C epidemic was studied using new technologies for the phylogenetic analysis of large datasets. Our results indicate that there is a major clade encompassing most of the South American HIV-1C strains. These analyses also agreed that some strains do not group inside this major clade, suggesting that there could be HIV-1C sequences of different origins circulating in South America. Others have proposed different hypotheses about the origins of HIV-1C strains from South America. This study shows that an exact single origin cannot be determined, a fact that could be attributed to sampling problems, phylogenetic uncertainty, and the shortage of historical and epidemiological data. Currently, the reported data indicate that HIV-1C strains were introduced in Brazil and afterward spread to other regions of South America. By using character optimization on the obtained phylogenetic trees, we observed that Argentina could also be a point in which the HIV-1C epidemic entered South America. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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