التفاصيل البيبلوغرافية
| العنوان: |
Sub-optimal efficacy of ivermectin against Parascaris equorum in foals on three Thoroughbred stud farms in the Manawatu region of New Zealand. |
| المؤلفون: |
Bishop, RM, Scott, I, Gee, EK, Rogers, CW, Pomroy, WE, Mayhew, IG |
| المصدر: |
New Zealand Veterinary Journal; Mar2014, Vol. 62 Issue 2, p91-95, 5p |
| مصطلحات موضوعية: |
IVERMECTIN, FOAL diseases, HORSE farms, FARMS, STRONGYLIDA diseases, DIAGNOSIS, THERAPEUTICS |
| مصطلحات جغرافية: |
NEW Zealand |
| مستخلص: |
AIM: To ascertain whether resistance was present inParascaris equorumto the macrocyclic lactone anthelmintic ivermectin, using faecal egg count reduction tests. METHODS: Thirty-nine foals aged between 11 and 28 weeks on three Thoroughbred stud farms (Farms A; n=20, B; n=5 and C; n=14) were treated with ivermectin (Day 0) and faecal egg counts (FEC) were monitored before and for 21 (Farms A and B) or 14 (Farm C) days after treatment. On Farms A and B, the foals were treated with a macrocyclic lactone/benzimidazole/praziquantel combination on Day 21 and FEC assessed on Day 35. The three farms were all in the Manawatu region in the southern half of New Zealand's North Island. RESULTS: Of the 39 foals, 15 were not sheddingP. equorumeggs on the day they were treated with ivermectin, but all 15 did so post-treatment. The FEC on Farms A and B showed no evidence of a reduction at any time between Day 7 and 21; egg output increased steadily over this period. Following combination treatment FEC were reduced by 94% on farm A and 100% on Farm B. On Farm C, there was a 69% reduction inP. equorumFEC on Day 14. Twelve of the 14 foals on Farm C were shedding strongylid eggs on Day 0 and on Day 14 FEC were reduced by 84%. CONCLUSIONS: Without comparison to untreated control animals, these results do not allow a reliable estimation of the exact level of efficacy of ivermectin againstP. equorum, but they nevertheless show that, within the farms studied, ivermectin no longer achieved a complete kill of egg-laying adults and that foals treated with this drug may continue to shed considerable numbers of eggs after treatment. The results also indicate that ivermectin had sub-optimal efficacy against strongylid nematodes on one of the farms. [ABSTRACT FROM PUBLISHER] |
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