دورية
Riluzole Series. Synthesis and in Vivo Antiglutamate Activity of 6-Substituted-2-benzothiazolamines and 3-Substituted-2-imino-benzothiazolines
| العنوان: | Riluzole Series. Synthesis and in Vivo Antiglutamate Activity of 6-Substituted-2-benzothiazolamines and 3-Substituted-2-imino-benzothiazolines |
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| المؤلفون: | Jimonet, P., Audiau, F., Barreau, M., Blanchard, J.-C., Boireau, A., Bour, Y., Coleno, M.-A., Doble, A., Doerflinger, G., Huu, C. Do, Donat, M.-H., Duchesne, J. M., Ganil, P., Gueremy, C., Honore, E., Just, B., Kerphirique, R., Gontier, S., Hubert, P., Laduron, P. M., Blevec, J. Le, Meunier, M., Miquet, J.-M., Nemecek, C., Pasquet, M., Piot, O., Pratt, J., Rataud, J., Reibaud, M., Stutzmann, J.-M., Mignani, S. |
| المصدر: | Journal of Medicinal Chemistry; July 29, 1999, Vol. 42 Issue: 15 p2828-2843, 16p |
| مستخلص: | Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2-benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-benzothiazolamines bearing alkyl, polyfluoroalkyl, or polyfluoroalkoxy substituents in the 6-position showed potent anticonvulsant activity against administration of glutamic acid in rats. The most active compounds displaying in vivo antiglutamate activity were the 6-OCF |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 00222623 15204804 |
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