دورية
Design and Pharmacological Activity of Phosphinic Acid Based NAALADase Inhibitors
| العنوان: | Design and Pharmacological Activity of Phosphinic Acid Based NAALADase Inhibitors |
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| المؤلفون: | Jackson, P. F., Tays, K. L., Maclin, K. M., Ko, Y.-S., Li, W., Vitharana, D., Tsukamoto, T., Stoermer, D., Lu, X.-C. M., Wozniak, K., Slusher, B. S. |
| المصدر: | Journal of Medicinal Chemistry; November 2001, Vol. 44 Issue: 24 p4170-4175, 6p |
| مستخلص: | A novel series of phosphinic acid based inhibitors of the neuropeptidase NAALADase are described in this work. This series of compounds is the most potent series of inhibitors of the enzyme described to date. In addition, we have shown that these compounds are protective in animal models of neurodegeneration. Compound |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 00222623 15204804 |
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