التفاصيل البيبلوغرافية
| العنوان: |
Growth and liver morphology after long-term ethanol consumption of rats |
| المؤلفون: |
van de Wiel, J. A. G., Duijf, C. M. P., Pertijs, J. C. L. M., Peereboom-Stegeman, J. H. J. Copius, Bos, R. P. |
| المصدر: |
Laboratory Animals; July 1990, Vol. 24 Issue: 3 p265-272, 8p |
| مستخلص: |
Ethanol was administered to female and male Wistar rats by mixing it with their drinking water. Ethanol concentrations were gradually increased up to either 8% or 15%.Female rats receiving 8% ethanol in their drinking water consumed 5-13 g, males 4-10 g daily. The ethanol/total food caloric intake percentages were 13 to 20% and 9 to 15% for female and male rats, respectively. There was no difference in body weight and relative liver weight between treated rats and their controls.Female and male rats receiving 15% of ethanol in their drinking water consumed 8-14 g ethanol per kg body weight per day. The percentages of ethanol/total food caloric intake were stabilized at about 25% for both sexes. Growth of the rats differed only slightly from controls; a tendency for a higher increase of body weight of the control rats was found. No difference in relative liver weight between ethanol-treated and control rats was observed. Microscopic examinations revealed that the ethanol treatment resulted in fat accumulation in the liver cells. A proliferation of the Smooth Endoplasmic Reticulum (SER) was more marked in the 15% dosed rats than in the 8% dosed rats and more distinct in female rats than in male rats in both dosage groups. |
| قاعدة البيانات: |
Supplemental Index |
