دورية
The Effect of Peroral Lynestrenol on Serum Lipids and Lipoproteins in Therapeutic Amenorrhea of Mentally Retarded Women
| العنوان: | The Effect of Peroral Lynestrenol on Serum Lipids and Lipoproteins in Therapeutic Amenorrhea of Mentally Retarded Women |
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| المؤلفون: | Huovinen, K., Tikkanen, M. J., Varonen, S., Wilska, M. -L., Westermarck, T., Vesterinen, H. |
| المصدر: | Acta Obstetricia et Gynecologica Scandinavica; 1990, Vol. 69 Issue: 1 p35-40, 6p |
| مستخلص: | Serum concentrations of total cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo A1), apolipoprotein 6 (Apo B), and triglyceride (TG) were measured and that of low density lipoprotein cholesterol (LDL-C) calculated in blood samples obtained from mentally handicapped women undergoing therapeutic amenorrhea (TA) induced by 5-10 mg of peroral lynestrenol, some receiving, some not receiving simultaneous anticonvulsant therapy Iphenytoin, carbamazepine or barbiturate, alone or in combination), In addition, these analyses were carried out in women receiving only anti-convulsants and in controls (mentally handicapped women not receiving any of the above-mentioned medications).Significantly lower HDL-C, Apo A1, TG and cholesterol concentrations were measured in TA patients receiving lynestrenol only, than in those receiving anticonvulsants only, or in controls (p<0.001). With regard to HDL-C and Apo A1, patients receiving both lynestrenol and anticonvulsants were intermediate between lynestrenol only patients and controls, but the HDL-C/LDL-C and Apo A1/Apo B ratios were similar to those observed in lynestrenol only patients.Addition of 8 or 12 mg of estriol succinate to the lynestrenol regimen was virtually without an effect. However, halving of the lynestrenol dose resulted in a significant increase in HDL-C and in the HDL-C/LDL-C and Apo A1/Apo B ratios (p<0.001 or p<0.01), respectively. The lynestrenol dose was thus the most important determinant of lipoprotein pattern and should be kept as small as possible in order to reduce cardiovascular risk. |
| قاعدة البيانات: | Supplemental Index |
PDF full text from Publisher | تدمد: | 00016349 16000412 |
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| DOI: | 10.3109/00016349009021036 |