دورية
Six-month pilot study of oestrogen replacement therapy with piperazine oestrone sulphate and its effect on memory
| العنوان: | Six-month pilot study of oestrogen replacement therapy with piperazine oestrone sulphate and its effect on memory |
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| المؤلفون: | Hackman, B. W., Galbraith, D. |
| المصدر: | Current Medical Research and Opinion; 1977, Vol. 4 Issue: 1, Supplement 3 p21-28, 8p |
| مستخلص: | SummaryEighteen patients (age range 29 to 68 years) completed a 6-month double-blind pilot study of piperazine oestrone sulphate. Ten patients presented with signs and symptoms of oestrogen deficiency; the remaining 8 had undergone hysterectomy and bilateral salpingo-oophorectomy in the 6 months preceding the start of the trial. Patients were randomly allocated to drug or placebo tablets. Those on active therapy took 1.5 mg piperazine oestrone sulphate twice daily; the control group took a placebo tablet twice daily. In every case, treatment was taken intermittently, with each 3-weeks' course of tablets followed by a week's interval before starting treatment again. In the active treatment group, hot flushes, dysuria, vaginal discomfort, dyspareunia and urinary symptoms, and insomnia were markedly improved. There was also a statistically significant improvement in memory after treatment. Clotting factors and other laboratory tests remained within normal limits during the course of treatment. |
| قاعدة البيانات: | Supplemental Index |
PDF full text from Publisher | تدمد: | 03007995 14734877 |
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| DOI: | 10.1185/03007997709109380 |