دورية
A New Cellular Model for In Vitro Biocompatibility Evaluation of Microcapsule Materials
| العنوان: | A New Cellular Model for In Vitro Biocompatibility Evaluation of Microcapsule Materials |
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| المؤلفون: | Zhang, Hua'an, Sun, Lin, Wang, Wei, Ma, Xiaojun |
| المصدر: | Key Engineering Materials; June 2005, Vol. 288 Issue: 1 p499-502, 4p |
| مستخلص: | Fibrosis caused by the host response to long-term transplanted microcapsules and the limitation of traditional L929 cell model for biocompatibility testing inspire the development of an assay of biocompatibility based on macrophage behavior. In this paper, the human monocytic cell line THP-1 was utilized for biocompatibility evaluation of microcapsule materials. The cell viability and secretion of nitric oxide (NO) and cytokines served as index of biocompatibility were assayed. It was found that the evaluated microcapsule materials had no effect on the stimulation of NO and cytokines secretion, which meant that these materials were biocompatible. Furthermore, it suggests the THP-1 cell a convenient in vitro experimental model that might be useful for long-term predictions of material biocompatibility. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 10139826 16629795 |
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| DOI: | 10.4028/www.scientific.net/KEM.288-289.499 |