دورية
Strategies for the targeted delivery of therapeutics for osteosarcoma
| العنوان: | Strategies for the targeted delivery of therapeutics for osteosarcoma |
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| المؤلفون: | Hughes, Dennis PM |
| المصدر: | Expert Opinion on Drug Delivery; January 2009, Vol. 6 Issue: 12 p1311-1321, 11p |
| مستخلص: | Background: Conventional therapy for osteosarcoma has reached a plateau of 60 – 70%, a 5-year survival rate that has changed little in two decades, highlighting the need for new approaches. Objective: To review the alternative means of delivering effective therapy for osteosarcoma that reach beyond the central venous catheter. Methods: Drawing on the author's own experiences providing care to high-risk osteosarcoma patients and reviewing the last two decades of literature describing sarcoma therapy, available information is summarized about potential osteosarcoma treatments that deliver therapy by a less conventional route. Results/conclusions: Intra-arterial chemotherapy has a limited impact on survival, but may help to achieve a better limb salvage. Intrapleural chemotherapy is important for managing malignant effusions. The development of inhalation therapies, treatments that target new bone formation such as bisphosphonates, chemically targeted radiation and antibody-based therapies all have potential to improve osteosarcoma therapy. |
| قاعدة البيانات: | Supplemental Index |
PDF full text from Publisher | تدمد: | 17425247 17447593 |
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| DOI: | 10.1517/17425240903280422 |