دورية
DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3TYPE 1 DIABETES GENE?
| العنوان: | DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3TYPE 1 DIABETES GENE? |
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| المؤلفون: | Podolin, Patricia L, Wilusz, Mary Beth, Cubbon, Rose M, Pajvani, Utpal, Lord, Christopher J, Todd, John A, Peterson, Laurence B, Wicker, Linda S, Lyons, Paul A |
| المصدر: | Cytokine; May 2000, Vol. 12 Issue: 5 p477-482, 6p |
| مستخلص: | The insulin-dependent diabetes (Idd) gene, Idd3, has been localised to a 0.35cM region of chromosome 3 containing the structural gene for the cytokine interleukin 2 (IL-2). While variation of the N-terminal amino acid sequence of IL-2 has been shown to correlate with Idd3allelic variation, differences in induction of proliferation by IL-2 allotypes have not been detected. In the current study, we examined the electrophoretic migration of IL-2 allotypes and have found two distinct patterns, consistent with differences in glycosylation, that correlate with diabetes-resistance and susceptibility. These findings strongly suggest that IL-2 variants may be functionally distinct. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 10434666 10960023 |
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| DOI: | 10.1006/cyto.1999.0609 |