دورية
Prevalence of post-partumthyroiditis in Liguria (Italy): An observational study
| العنوان: | Prevalence of post-partumthyroiditis in Liguria (Italy): An observational study |
|---|---|
| المؤلفون: | Filippi, U., Brizzolara, R., Venuti, D., Cesarone, A., Maritati, V., Podestà, M., Yung, W., Bottaro, L., Orselli, A., Chiappori, A., Schiavo, M., Caputo, M., Bonassi, S., Bagnasco, M. |
| المصدر: | Journal of Endocrinological Investigation; December 2008, Vol. 31 Issue: 12 p1063-1068, 6p |
| مستخلص: | Background: Postpartum thyroiditis (PPT) is an autoimmune disorder occurring within the first year following delivery. A variable prevalence has been reported in different surveys. We prospectively evaluated PPT prevalence and outcome in a cohort of pregnant women living in a well-defined geographic area. Aim: A subset from a group of healthy women consecutively evaluated for thyroid function and thyroid autoimmunity during pregnancy, referring to the same obstetric unit, were followed up at 4–6 months and 1 yr after delivery. Materials/subjects and methods: Follow-up for PPT was performed in 258 pregnant women. Control data were obtained in a comparable group of healthy non-pregnant women. Free T3(fT3), free T4(fT4), TSH thyroglobulin/thyroid peroxidase autoantibodies (TgAb/TPOAb), and urinary iodine excretion were measured. Results: Autoanti-body positivity was observed in 9.3% of pregnant, similar to control women. Forty-three out of 59 autoantibody-positive women were followed up; 23 showed PPT at the first control, 18 had hypothyroidism at 1 yr (5 had not shown PPT at the first control). Among 215 out of 584 autoantibody-negative women followed up, 27 developed PPT (15 of them without thyroid autoantibodies); 16 developed thyroid autoantibodies without PPT. After 1 yr, 9 women had hypothyroidism: only 1 of them was autoantibody-negative at the former control. Urinary iodine was increased in several pregnant women. Conclusions: An overall PPT prevalence of about 18% may be estimated. PPT was also observed in autoantibody-negative women. Differences with other surveys may be related to both study protocol and characteristics of the population studied. |
| قاعدة البيانات: | Supplemental Index |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 03914097 17208386 |
|---|---|
| DOI: | 10.1007/BF03345653 |