دورية
Echinococcus granulosusdown regulates the hepatic expression of inflammatory cytokines IL-6 and TNFα in BALB/c mice
| العنوان: | Echinococcus granulosusdown regulates the hepatic expression of inflammatory cytokines IL-6 and TNFα in BALB/c mice |
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| المؤلفون: | Mondragón-De-La-Peña, C., Ramos-Solís, S., Barbosa-Cisneros, O., Rodríguez-Padilla, C., Tavizón-García, P., Herrera-Esparza, R., Mondragón-De-La-Peña, C., Ramos-Solís, S., Barbosa-Cisneros, O., Rodríguez-Padilla, C., Tavizón-García, P., Herrera-Esparza, R. |
| المصدر: | Parasite - Journal de la Société Française de Parasitologie; December 2002, Vol. 9 Issue: 4 p351-356, 6p |
| مستخلص: | Hydatid disease is caused by the metacestode of Echinococcus granulosus. Different experimental models have been used to understand hydatid disease. In current studies BALB/c mice were used to evaluate the hepatic response of IL-6 and TNFα triggered by Echinococcus granulosus.BALB/c mice were intraperitoneally infected with protoscoleces from E. granulosus; hydatid cysts appeared on the liver eight weeks after inoculation. The RNA extracted from hepatic sections was used for RT-PCR amplification with primers for IL-6, TNFα, IL-10, TGFβ and G3PDH. In situcytokine expression was assessed by FISH. Complete parasite cysts on the liver surface were observed 16 weeks after infection ; controls were negative. The expression of IL-6 and TNFα was normal at baseline and declined progressively eight weeks after infection ; in some animals such expression was abrogated 16 weeks after infection. On the other hand IL-10 and TGFβ were increased progressively. Controls expressed the cytokines normally. Present results suggest that E. granulosusinduces a local immunosupression probably mediated by IL-10 and TGFβ ; therefore it seems possible that such a mechanism would assist the parasite in escaping the harmful host cell-mediated response. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 1252607X 17761042 |
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| DOI: | 10.1051/parasite/2002094351 |