دورية
Synthesis and Skeletal Muscle Relaxant Activity of 3- (aminoacyl)-1-[[[5- (substituted phenyl)-2- Furanyl]methylene]amino]-2, 4-imidazolidinediones
| العنوان: | Synthesis and Skeletal Muscle Relaxant Activity of 3- (aminoacyl)-1-[[[5- (substituted phenyl)-2- Furanyl]methylene]amino]-2, 4-imidazolidinediones |
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| المؤلفون: | Wessels, F.L., Ellis, K.O., White, R.L. |
| المصدر: | Journal of Pharmaceutical Sciences; September 1981, Vol. 70 Issue: 9 p1088-1090, 3p |
| مستخلص: | A series of 3-(aminoacyl)-1-[[[5-(substituted phenyl)-2-furanyl]methylene]amino]-2, 4-imidazolidinediones was synthesized and evaluated for skeletal muscle relaxant activity. All compounds were active by the intravenous route, and nine of 11 were active orally. One compound was very active when evaluated by the mouse Straub tail and rotarod tests; its efficacy index (ED50rotarod/ED50Straub tail) was 2.0, while its therapeutic index (LD50/ED50Straub tail) was >225. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00223549 15206017 |
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| DOI: | 10.1002/jps.2600700933 |