دورية
Pharmacology of 1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone, a novel antidepressant compound with antianxiety activity
| العنوان: | Pharmacology of 1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone, a novel antidepressant compound with antianxiety activity |
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| المؤلفون: | Ellis, K.O., Wessels, F.L., Burns, R.H., Pong, S.F. |
| المصدر: | Journal of Pharmaceutical Sciences; October 1980, Vol. 69 Issue: 10 p1198-1202, 5p |
| مستخلص: | 1-(3,4-Dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone (I) was evaluated in selected pharmacological tests, and its activity was compared to that of some clinically useful psychotropic drugs. Based on the results, it is evident that I has a unique profile of antidepressant and antianxiety activities that are evident in the same dose range. The mechanism of its antidepressant activity is proposed to be similar to the tricyclic antidepressants, that is, inhibition of norepinephrine uptake. Neither I nor the tricyclic antidepressants possess monoamine oxidase-inhibiting activity. However, unlike the tricyclic antidepressants, I is devoid of any significant anticholinergic activity and presumably is free of anticholinergic side effects. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00223549 15206017 |
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| DOI: | 10.1002/jps.2600691021 |