دورية
Preliminary in vitroevaluation of the anti-proliferative activity of guanylhydrazone derivatives
| العنوان: | Preliminary in vitroevaluation of the anti-proliferative activity of guanylhydrazone derivatives |
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| المؤلفون: | França, Paulo H. B., Da Silva-Júnior, Edeildo F., Aquino, Pedro G. V., Santana, Antônio E. G., Ferro, Jamylle N. S., De Oliveira Barreto, Emiliano, Do Ó Pessoa, Cláudia, Meira, Assuero Silva, De Aquino, Thiago M., Alexandre-Moreira, Magna S., Schmitt, Martine, De Araújo-Júnior, João X. |
| المصدر: | Acta Pharmaceutica; March 2016, Vol. 66 Issue: 1 p129-137, 9p |
| مستخلص: | Guanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma), MDA-MB-435 (melanoma) and SF-295 (glioblastoma) were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibition of tumor cell lines and macrophages J774 was measured using tetrazolium salt (MTT) assay. Compounds 7, 11, 16and 17showed strong cytotoxic activity with IC50values lower than 10 μmol L−1against four tumor cell lines. Among them, 7was less toxic to non-tumor cells. Finally, obtained data suggest that guanylhydrazones may be regarded as potential lead compounds for the design of novel anticancer agents. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 13300075 18469558 |
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| DOI: | 10.1515/acph-2016-0015 |