دورية
Primary liver cancer in genetic hemochromatosis: A clinical, pathological, and pathogenetic study of 54 cases
| العنوان: | Primary liver cancer in genetic hemochromatosis: A clinical, pathological, and pathogenetic study of 54 cases |
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| المؤلفون: | Deugnier, Yves M., Guyader, Dominique, Crantock, Luke, Lopez, José-Manuel, Turlin, Bruno, Yaouanq, Jacqueline, Jouanolle, Hervé, Campion, Jean-Pierre, Launois, Bernard, Halliday, June W., Powell, Lawrie W., Brissot, Pierre |
| المصدر: | Gastroenterology; January 1993, Vol. 104 Issue: 1 p228-234, 7p |
| مستخلص: | Background: Although liver cancer arises frequently in the course of genetic hemochromatosis (GH), it has not been previously studied in a large series of patients with well-defined GH. Methods: The bioclinical and pathological data from 1 cholangiocarcinoma and 53 hepatocellular carcinomas (HCCs) complicating GH in 32 untreated and 22 de-ironed patients are reported. Results: This study (1) adds three new well-documented cases of HCC in noncirrhotic but only fibrotic hemochromatotic liver, (2) shows the high prevalence (83%) of proliferative and often dysplastic (70%) iron-free foci in the nontumorous liver of untreated patients, and (3) emphasizes the significant increase of cirrhosis (81% vs. 28%) and of associated noniron-related risk factors, mainly chronic alcoholism (48% vs. 25%) and tobacco smoking (50% vs. 18%) in patients with HCC compared with matched hemochromatotic patients without HCC. Conclusions: These data (1) suggest that iron-free foci may be markers of an early stage of HCC in GH and (2) supply the basis for defining a cost-effective policy for the screening of HCC in GH patients. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00165085 15280012 |
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| DOI: | 10.1016/0016-5085(93)90856-8 |