دورية
Opposite effects of κ-opioid agonists on gastric emptying of liquids and solids in dogs
| العنوان: | Opposite effects of κ-opioid agonists on gastric emptying of liquids and solids in dogs |
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| المؤلفون: | Gue, M., Fioramonti, J., Honde, C., Pascaud, X., Junien, J.L., Bueno, L. |
| المصدر: | Gastroenterology; October 1988, Vol. 95 Issue: 4 p927-931, 5p |
| مستخلص: | The influence of oral (p.o.) administration of κ-(U-50488, tifluadom) and μ- (morphine, DAGO) opioid substances on gastric emptying of liquids and solids in a standard canned dog food meal was evaluated using a double-radiolabeled technique in dogs fitted with gastric cannulas. One hour after feeding, 28.6% ± 3.6% (mean ± SD) of the solid phase and 27.1% ± 8.6% of the liquid phase of the meal had been emptied. Both U-50488 and tifluadom given orally (0.01–0.1 mg/kg) significantly increased (p < 0.05) the 1-h emptying of the solid phase of the meal by 23.1%–49.6%. In contrast, both drugs significantly reduced emptying of liquids. These effects were not reproduced when similar doses were given intravenously. Oral administration of morphine or DAGO (0.01–0.1 mg/kg) did not affect gastric emptying, whereas an inhibited emptying of solids was observed for morphine at a higher dose (1 mg/kg p.o.). At a dose of 100 μg/kg i.v. both naloxone and MR 2266 (0.1 mg/kg) abolished the effects of orally administered U-50488 on gastric emptying of solids and liquids. It is concluded that κ- but not μ-agonists act locally to alter gastric emptying of a standard meal in dogs, having opposite effects on solid and liquid phases. A selective local stimulation of κ mucosal or submucosal receptors of the gastroduodenal area may explain such effects. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00165085 15280012 |
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| DOI: | 10.1016/0016-5085(88)90165-5 |