دورية
أعرض في EDS

Evaluation of the antioxidant property and effects in Caenorhabditis elegansof Xiangxi flavor vinegar, a Hunan local traditional vinegar

التفاصيل البيبلوغرافية
العنوان: Evaluation of the antioxidant property and effects in Caenorhabditis elegansof Xiangxi flavor vinegar, a Hunan local traditional vinegar
المؤلفون: Huang, Run-ting, Huang, Qing, Wu, Gen-liang, Chen, Chun-guang, Li, Zong-jun
المصدر: Journal of Zhejiang University - Science B; April 2017, Vol. 18 Issue: 4 p324-333, 10p
مستخلص: Xiangxi flavor vinegar (XV) is one of Hunan Province’s traditional fermented vinegars. It is produced from herb, rice, and spring water with spontaneous liquid-state fermentation techniques. In this study, we investigated the antioxidant property of XV by analyzing its antioxidant compounds, its free radical scavenging property in vitro and in vivo, and its effects on antioxidant enzyme activity and apoptosis in Caenorhabditis elegans. The results showed that XV is rich in antioxidants. In particular, ligustrazine reached 6.431 μg/ml. The in vitro 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH•), hydroxyl radical (•OH), and superoxide anion radical (O2•−) scavenging rates of XV were 95.85%, 97.22%, and 63.33%, respectively. The reactive oxygen species (ROS) content in XV-treated C. elegansdecreased significantly (P<0.01) compared to the control group. Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities were remarkably increased (P<0.01) in C. elegansafter XV treatment. In addition, XV could upregulate CED-9 protein expression and downregulate CED-3 protein expression in C. elegans. These results prove that XV is rich in antioxidants and scavenges radicals in vitro efficiently. XV inhibits apoptosis in C. elegansprobably by scavenging ROS and increasing the activities of its antioxidant enzymes.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:16731581
18621783
DOI:10.1631/jzus.B1600088