دورية
An Improved Synthesis of Amantadine Hydrochloride
| العنوان: | An Improved Synthesis of Amantadine Hydrochloride |
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| المؤلفون: | Vu, Duong Binh, Nguyen, Thinh Van, Le, Son Trung, Phan, Chau Dinh |
| المصدر: | Organic Process Research & Development; 20240101, Issue: Preprints |
| مستخلص: | Amantadine hydrochloride 1is an antiviral drug used in the prevention and treatment of influenza A infections. It has also been used for alleviating early symptoms of Parkinson’s disease. Several methods for the preparation of 1have been reported. These procedures started with adamantane 2using as many as four reaction steps to produce amantadine hydrochloride with overall yields ranging from 45% to 58%. In this article, we describe a two-step procedure for the synthesis of 1from 2via N-(1-adamantyl)acetamide 4with an improved overall yield of 67%. The procedure was also optimized to reduce the use of toxic solvents and reagents, rendering it more environment-friendly. The procedure can be considered as suitable for large-scale production of amantadine hydrochloride. The structure of amantadine hydrochloride was confirmed by 1H NMR, 13C NMR, IR, and MS. |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 10836160 1520586X |
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| DOI: | 10.1021/acs.oprd.7b00242 |