دورية
Interleukin‐4 biases differentiation of B cells from Trypanosoma cruzi‐infected mice and restrains their fratricide: role of Fas ligand down‐regulation and MHC class II‐transactivator up‐regulation
| العنوان: | Interleukin‐4 biases differentiation of B cells from Trypanosoma cruzi‐infected mice and restrains their fratricide: role of Fas ligand down‐regulation and MHC class II‐transactivator up‐regulation |
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| المؤلفون: | Acosta Rodriguez, E. V., Zuñiga, E., Montes, C. L., Gruppi, A. |
| المصدر: | Journal of Leukocyte Biology; January 2003, Vol. 73 Issue: 1 p127-136, 10p |
| مستخلص: | In the present work, we demonstrate that interleukin (IL)‐4 is able to rescue B cells from Trypanosoma cruzi‐infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL‐4 restrains the apoptosis of immunoglobulin (Ig)M+and IgG+B cells from infected and normal mice without inducing them to proliferate. In addition, IL‐4 does not modify the quantity or quality of the antibodies secreted by B cells from infected mice, as it blocks their terminal differentiation to plasma cells and favors memory pathway. It is interesting that the protective effect of IL‐4 over B cells from infected mice is mediated, at least partly, by the down‐regulation of Fas ligand (FasL) expression, which leads to interference in the apoptosis executed by these B cells through the Fas/FasL death pathway. Accordingly, a marked up‐regulation of the “FasL gene repressor” class II transactivator was observed, suggesting that this would be one mechanism underlying the IL‐4‐mediated FasL down‐regulation. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 07415400 19383673 |
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| DOI: | 10.1189/jlb.0702353 |