التفاصيل البيبلوغرافية
| العنوان: |
Whole-genome sequencing and single nucleotide polymorphisms in multidrug-resistant clinical isolates of Mycobacterium tuberculosisfrom the Philippines |
| المؤلفون: |
Roa, Marylette B., Tablizo, Francis A., Morado, El King D., Cunanan, Lovette F., Uy, Iris Diana C., Ng, Kamela Charmaine S., Manalastas-Cantos, Karen G., Reyes, Joeriggo M., Ganchua, Sharie Keanne C., Ang, Concepcion F., Kato-Maeda, Midori, Cattamanchi, Adithya, Karaoz, Ulas, Destura, Raul V., Lluisma, Arturo O. |
| المصدر: |
Journal of Global Antimicrobial Resistance; December 2018, Vol. 15 Issue: 1 p239-245, 7p |
| مستخلص: |
•The Philippines is among the top countries in the world with a high TB burden.•WGS was utilised to investigate drug resistance in clinical M. tuberculosisisolates.•katGSer315Thr, rpoBSer450Leu and embB Met306Val were found in resistant isolates.•Mutations in the inhApromoter and in pncAand gyrAgenes were also observed.•WGS is a useful tool to study M. tuberculosisresistance in high-burden settings. |
| قاعدة البيانات: |
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