دورية
Bimetallic Oxide MnMoOXNanorods for in Vivo Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy
| العنوان: | Bimetallic Oxide MnMoOXNanorods for in Vivo Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy |
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| المؤلفون: | Gong, Fei, Cheng, Liang, Yang, Nailin, Jin, Qiutong, Tian, Longlong, Wang, Mengyun, Li, Yonggang, Liu, Zhuang |
| المصدر: | Nano Letters; August 2018, Vol. 18 Issue: 9 p6037-6044, 8p |
| مستخلص: | Accurate imaging of glutathione (GSH) in vivo is able to provide real-time visualization of physiological and pathological conditions. Herein, we successfully synthesize bimetallic oxide MnMoOXnanorods as an intelligent nanoprobe for in vivo GSH detection via photoacoustic (PA) imaging. The obtained MnMoOXnanoprobe with no near-infrared (NIR) absorption in the absence of GSH would exhibit strong GSH-responsive NIR absorbance, endowing PA imaging detection of GSH. Due to the up-regulated GSH concentration in the tumor microenvironment, our MnMoOXnanoprobe could be utilized for in vivo tumor-specific PA imaging. Moreover, MnMoOXnanorods with GSH-responsive NIR absorbance could also be employed to achieve tumor-specific photothermal therapy (PTT). Importantly, such MnMoOXnanorods show inherent biodegradability and could be rapidly cleared out from the body, minimizing their long-term body retention and potential toxicity. Our work presents a new type of GSH-responsive nanoprobe based on bimetallic oxide nanostructures, promising for tumor-specific imaging and therapy. |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 15306984 15306992 |
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| DOI: | 10.1021/acs.nanolett.8b02933 |