التفاصيل البيبلوغرافية
| العنوان: |
In Vitro and In Vivo Study of Argyreia speciosaon Chronic Gastric Ulceration and Metabolic Studies |
| المؤلفون: |
Azmi, Lubna, Shukla, Ila, Gupta, Shyam, Yadav, Narayan, Kant, Padam, Rao, Ch. |
| المصدر: |
Proceedings of the National Academy of Sciences, India Section B; September 2019, Vol. 89 Issue: 3 p1039-1045, 7p |
| مستخلص: |
Chronic gastric ulcer being the most prevalent gastrointestinal disorder is considered a major cause of gastric cancer. Large numbers of synthetic drugs ranging from proton-pump inhibitors and H2receptor antagonist to cytoprotective agents are available, but they have major side effects. Inadequacy of these synthetic drugs forces to develop new herbal-based drugs active against chronic gastric ulcer. In the present study, antiulcer activity of butanolic extract of Argyreia speciosaLinn. f., Sweet: Family Convolvulaceae (b-ASL) was investigated against acetic-acid-induced chronic gastric ulcer rat models. The effect of different dose of butanolic extract of A. speciosawas studied for antioxidant, anti-secretory, and cytoprotective activities. Extract administration significantly increased the gastric PGE2content. The further experiments including the in vitro metabolic stability and in vivo pharmacokinetics gave a clear indication that butanolic extract of A. speciosa(200 mg/kg) is an orally active and safe contender of antiulcer agents. It can be an important target for further studies under chronic ulcer management system. |
| قاعدة البيانات: |
Supplemental Index |
Find this article in full text from Springer Verlag. 
Full Text Finder