دورية
Identification of polyphenolic composition in the fruits of Rubus chingiiHu and its antioxidant and antiproliferative activity on human bladder cancer T24 cells
| العنوان: | Identification of polyphenolic composition in the fruits of Rubus chingiiHu and its antioxidant and antiproliferative activity on human bladder cancer T24 cells |
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| المؤلفون: | Li, Kuangyu, Zeng, Maolin, Li, Qiaoling, Zhou, Benhong |
| المصدر: | Journal of Food Measurement and Characterization; March 2019, Vol. 13 Issue: 1 p51-60, 10p |
| مستخلص: | Rubus chingiiHu, namely “Fu-pen-zi” in Chinese, is commonly used as a functional food in China. A rapid and sensitive High performance liquid chromatography (HPLC) coupled with linear ion trap-OrbiTrap hybrid mass spectrometer (LTQ OrbiTrap MS) was employed to identify the polyphenolic compounds in R. chingiifruits. A total of 18 compounds were identified in R. chingiipolyphenols (RCPs), including five phenolic acids, four ellagitannins, and nine flavonoids. Additionally, the total phenolics, total flavonoids and total tannins content as well as antioxidant and antiproliferative activity were evaluated for the first time. The contents of total phenolics, total flavonoids, and total tannins were 356.42 mg GAE g−1of extract, 201.94 mg RUE g−1of extract and 155.12 mg GAE g−1of extract, respectively. Antioxidant assays showed RCPs had favorable DPPH and OH−radical scavenging capacity and strong ferric ion reducing power. Moreover, the results also indicated the RCPs could inhibit cell proliferation and induce the cell apoptosis in T24 bladder cancer cells. Altogether, the results suggest R. chingiipossesses potent antioxidant properties and could inhibit the growth of T24 cells by inducing the cell apoptosis in a dose-dependent manner. |
| قاعدة البيانات: | Supplemental Index |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21934126 21934134 |
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| DOI: | 10.1007/s11694-018-9918-x |