التفاصيل البيبلوغرافية
| العنوان: |
Hydrocortisone inhibits prostaglandin production but not arachidonic acid release from cultured macrophages |
| المؤلفون: |
Wood, John N., Coote, Paul R., Rhodes, John |
| المصدر: |
FEBS Letters; August 1984, Vol. 174 Issue: 1 p143-146, 4p |
| مستخلص: |
We have investigated the action of hydrocortisosone on arachidonic acid mobilisation in cultures of mouse peritoneal macrophages, mouse L929cells and the mouse macrophage‐like cell line RAW264. Hydrocortisone inhibits both arachidonic acid release and prostaglandin production by L929cells. However, prostaglandin production by macrophages or RAW264cells is inhibited with a concomitant stimulation rather than inhibition of arachidonic acid release. These data suggest that hydrocortisone acts at the level of phospholipase activity in fibroblasts but at a later stage of prostanoid production in macrophages. |
| قاعدة البيانات: |
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