التفاصيل البيبلوغرافية
| العنوان: |
Interactions of the HIV‐1 reverse transcriptase ‘AZT‐resistant’ mutant with substrates and AZT‐TP |
| المؤلفون: |
Pokholok, Dmitry K., Gudima, Severin O., Yesipov, Dmitry S., Dobrynin, Vladimir N., Rechinsky, Vladimir O., Kochetkov, Sergey N. |
| المصدر: |
FEBS Letters; July 1993, Vol. 325 Issue: 3 p237-241, 5p |
| مستخلص: |
To investigate the biochemical basis of the HIV‐1 resistance to AZT we obtained the RT mutant containing four amino acid substitutions by an oligonucleotide‐directed mutagenesis technique. Enzymatic properties of the wild type and mutant RTs were compared. ‘AZT‐resistant’ mutations in RT were shown to be associated with the reduced capability of AZT‐TP to block the DNA‐ but not RNA‐directed DNA synthesis. |
| قاعدة البيانات: |
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