التفاصيل البيبلوغرافية
| العنوان: |
Infection of cattle by airborne foot-and-mouth disease virus: minimal doses with O1and sat2 strains |
| المؤلفون: |
DONALDSON, A.I., GIBSON, C.F., OLIVER, R., HAMBLIN, C., KITCHING, R.P. |
| المصدر: |
Research in Veterinary Science; November 1987, Vol. 43 Issue: 3 p339-346, 8p |
| مستخلص: |
Equipment has been constructed and methods developed for exposing individual cattle to two strains of foot-and-mouth disease (fmd) virus in aerosols to determine the minimal infective dose by the respiratory route. The aerosols used were produced either artificially by a spinning-top aerosol generator, in which case they were of homogeneous small particle size (less than 3 µm in diameter) or else they were derived naturally from infected pigs, in which case the particles were heterogeneous in size. Two strains of fmdvirus were used: an O1strain of ukorigin and a sat2 strain from South Africa. The lowest doses which initiated infection were 12·5 tcid50 of O1bfsvirus and 25 tcid50of sat2 virus, infectivity having been assayed in primary bovine thyroid cell cultures. Following exposure to low doses of virus (range 12 to 316 tcid50) 33 per cent of the cattle exposed to O1bfsvirus and 27 per cent exposed to sat 2virus were infected but did not develop detectable vesicular lesions. |
| قاعدة البيانات: |
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