التفاصيل البيبلوغرافية
| العنوان: |
TLR3and TLR4SNP variants in the liver disease resulting from hepatitis B virus and hepatitis C virus infection |
| المؤلفون: |
Sghaier, I, Zidi, S, Mouelhi, L, Ghazoueni, E, Brochot, E, Almawi, WY, Loueslati, BY |
| المصدر: |
British Journal of Biomedical Science; January 2019, Vol. 76 Issue: 1 p35-41, 7p |
| مستخلص: |
ABSTRACTBackground: Chronic infection with hepatitis B (HBV) and C virus (HCV) is linked with a pro-inflammatory state, predisposing to cirrhosis and liver cancer, particularly hepatocellular carcinoma (HCC). A role for Toll-like receptor (TLR) signalling in hepatocarcinogenesis was recently documented. We hypothesised a link TLR3 and TLR4 polymorphisms and HCC, as surrogates for the significance of TLR signalling in the promotion and initiation of HCC.Materials and methods: We recruited 174 HCV-infected patients, 100 HBV-infected patients and 360 healthy control subjects. TLR3(rs3775290) and TLR4(rs4986790) genotyping was done by PCR-restriction fragment length polymorphisms (PCR-RFLP), LFTs and AFP by standard routine techniques. Liver fibrosis was assessed clinically by the Fibrotest and Actitest.Result: The TLR3rs3775290 minor T genotype was linked with increased risk of chronic HBV (P= 0.05) and HCV (P= 0.031) infection. The TLR4rs4986790 minor G genotype was linked with significantly increased risk for HBV/HCV chronic infection (P< 0.001). Subgroups analyses indicated decreased risk of HBV-related HCC in relation to TLR3rs3775290 CC/CT genotype (P= 0.022), with increased risk ascribed to the minor (T) allele (P= 0.04). Likewise, TLR4rs4985790 minor (GG) genotype was positively associated with HBV-linked HCC (P< 0.001). Furthermore, a link between TLR3TT (P< 0.001) andTLR4GG (P= 0.04) minor genotypes was noted in relation to increased risk of HCV-related disease.Conclusion: TLR3and TLR4polymorphisms are promising biomarkers of liver cirrhosis and cancer associated with HBV and HCV infection. |
| قاعدة البيانات: |
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